GLP-1 Explained
26 articles

How GLP-1 Works

The mechanisms behind GLP-1 medicine.

GLP-1 & Bone Health: Osteoporosis Risk, Fracture Studies & Protection Guide (2024) → GLP-1 & Food Noise: How Semaglutide Silences Constant Food Thoughts → GLP-1 Agonists for PCOS: Insulin Resistance Mechanism, Liraglutide Ovulation Data, Androgen Excess Reduction, and the Emerging Fertility Evidence → GLP-1 for PCOS: Weight Loss, Insulin Resistance, and Fertility Outcomes (2026) → GLP-1 Agonists for PCOS: Insulin Resistance, Weight Loss & Hormonal Benefits → GLP-1 & Sleep Apnea: SURMOUNT-OSA Trial, Tirzepatide AHI Reduction 63%, Semaglutide OSA Data, vs. CPAP → GLP-1 and Sleep Apnea: SURMOUNT-OSA Trial, Tirzepatide AHI Reduction, Upper Airway Fat Mechanism, and Whether GLP-1s Can Replace CPAP → GLP-1 Medications and Sleep Quality: The Sleep Apnea Breakthrough → GLP-1 Medications and Type 2 Diabetes: HbA1c Reduction, Beta Cell Preservation & Remission Evidence → GLP-1 vs Bariatric Surgery: RYGB, Sleeve Gastrectomy & Semaglutide Weight Loss Comparison (2026) → GLP-1 vs Metformin: Head-to-Head Comparison for Type 2 Diabetes and Weight Loss (2026) → GLP-1 Weight Loss Plateau: Science-Backed Strategies to Break Through → GLP-1 Weight Loss Plateau: Why It Happens and What to Do (2026) → GLP-1 Weight Loss Plateau: Muscle Preservation, Protein & Resistance Training Guide → How GLP-1 Medications Work → Insulin Resistance: The Cellular Mechanisms Behind Type 2 Diabetes and How GLP-1 Agonists Reverse It (2026) → Muscle Loss on GLP-1 Medications: How to Prevent It → Ozempic Plateau: Why Weight Loss Stalls on GLP-1 and What to Do (2026) → Ozempic Plateau: Why Weight Loss Stalls on GLP-1 Drugs and What to Do (2026) → Retatrutide & Next-Gen GLP-1 Agonists: Triple Agonist Science, Pipeline & 2026–2028 FDA Timeline → Semaglutide vs Tirzepatide Weight Loss: STEP 1 (−14.9%), SURMOUNT-1 (−20.9%), GLP-1 + GIP Dual Agonism, Gastric Emptying, Central Appetite Suppression → Semaglutide vs Liraglutide: Ozempic/Wegovy vs Victoza/Saxenda → Tirzepatide vs Semaglutide: SURMOUNT-1 (Jastreboff 2022, NEJM, N=2,539, Tirzepatide 15mg −20.9% Body Weight) vs STEP 1 (Wilding 2021, N=1,961, Semaglutide 2.4mg −14.9%), Dual GIP+GLP-1 Agonism vs Mono GLP-1, SURPASS-2 Head-to-Head, and When Each Drug Wins (2026) → Tirzepatide vs Semaglutide Head-to-Head: SURMOUNT-5 Trial Results, 20.2% vs 13.7% Weight Loss, Dual GIP/GLP-1 Mechanism, and Which Patients Benefit Most From Each Agent → Tirzepatide vs Semaglutide: Weight Loss Comparison → Tirzepatide vs Semaglutide: The 2024 Head-to-Head Weight Loss Breakdown →
Related Guides

Related reading

A resource for your family
Scam calls targeting older adults are at record levels — the FBI logged $7.75 billion in reported losses from adults 60+ in 2025. Our free, no-signup guides show families exactly how the calls work — and the four rules that stop them.
Visit Scam-Proof Your Parents →
Weekly Research Digest
Get the free GLP-1 Protocol Log - plus the weekly digest

A 12-week fillable log: injections and site rotation, side effects, daily protein against a muscle-preservation target, and the page you bring to your prescriber.

No spam. Unsubscribe any time.
Losing weight? Don't lose muscle.
Up to 40% of GLP-1 weight loss can be muscle. The GLP-1 Protein Playbook shows you exactly how to protect it — with 25 high-protein meals that go down easy on a killed appetite.
Get the Playbook → $19